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Is made in several countries, including the U. [8] [20] It is on the World Health Organization's List of Essential Medicines. Metformin was discovered in 1922. · A very popular medicine, called Premarin, is actually made from horse urine of pregnant mares. Officinaliswas found to be rich in guanidine, a substance with blood glucose-lowering activity that formed the chemical basis of metformin. Created by Bristol-Myers Squibb Company, Metformin is approved in the US and the UK as a treatment for type 2 diabetes. The metformin recall noted in this post is specific to two lots in Kansas City, Missouri, the location of Nostrum Laboratories, Inc. Other Names for Metformin Metformin is sold both under brand names, and also as a generic drug Metformin hydrochloride is the scientific or generic name for the active ingredient in tablets sold in Australia under 40 different proprietary or brand names. We found the packaging of that particular version. [19] French physician Jean Sterne began the study in humans in the 1950s. [4] [11] Metformin is in the biguanide class. Click here to read our Diabetes and Metformin FAQs including information on lactic acidosis. This has been one of the most prescribed drugs in the United States.. [4] It works by decreasing glucose production by the liver and increasing the insulin sensitivity of body tissues. [12] French physician Jean Sterne began study in humans in the 1950s. [19] It was introduced as a medication in France in 1957 and the United States in 1995. [4] Metformin was discovered in 1922.